Squalane

Goodemollient

A stable emollient that moisturizes and softens the skin.

What is Squalane?

CAS Number

111-01-3

Formula

C30H62

Molecular Weight

422.83 g/mol

Also known as: Hydrogenated Squalene, Perhydrosqualene

What does Squalane do for skin?

Saturated (hydrogenated) form of squalene, a natural component of human sebum (constitutes ~13% of skin surface lipids). Biomimetic emollient that integrates into the lipid matrix of the stratum corneum. Non-comedogenic due to molecular size and structure. Antioxidant activity via quenching singlet oxygen. Enhances penetration of other active ingredients by disrupting lipid packing.

Typical concentration: 1-100% (can be used neat as a facial oil)

Is Squalane safe?

Excellent safety profile. Non-comedogenic. CIR Expert Panel: safe as used in cosmetics. Derived from plant sources (olive, sugarcane) in modern formulations. Stable and non-oxidizing unlike squalene.

What does the research say about Squalane?

Regulatory Info

Status: Approved
Restrictions: 2,6,10,15,19,23-Hexamethyltetracosane

Can I mix Squalane with other ingredients?

Info

General guidance

Squalane and face oils should be your last step (before SPF in AM). They create an occlusive layer that seals everything in.

Info

Retinoids

Squalane after retinoid helps lock in moisture and reduce dryness. It's non-comedogenic so it won't clog pores.

Read all ingredient interaction guides for layering order and science-backed advice.

All Ingredients

Frequently Asked Questions

What does Squalane do in skincare?+

A stable emollient that moisturizes and softens the skin. Saturated (hydrogenated) form of squalene, a natural component of human sebum (constitutes ~13% of skin surface lipids). Biomimetic emollient that integrates into the lipid matrix of the stratum corneum. Non-comedogenic due to molecular size and structure. Antioxidant activity via quenching singlet oxygen. Enhances penetration of other active ingredients by disrupting lipid packing.

Is Squalane safe for sensitive skin?+

Excellent safety profile. Non-comedogenic. CIR Expert Panel: safe as used in cosmetics. Derived from plant sources (olive, sugarcane) in modern formulations. Stable and non-oxidizing unlike squalene.

What percentage of Squalane should I look for?+

Look for products with 1-100% (can be used neat as a facial oil) for clinical efficacy.

Can I use Squalane with General guidance?+

Squalane can be used with General guidance. Squalane and face oils should be your last step (before SPF in AM). They create an occlusive layer that seals everything in.

Can I use Squalane with Retinoids?+

Squalane can be used with Retinoids. Squalane after retinoid helps lock in moisture and reduce dryness. It's non-comedogenic so it won't clog pores.

Further Reading