Hyaluronic Acid

Goodhumectant

Humectant that draws moisture into skin.

What is Hyaluronic Acid?

CAS Number

9004-61-9

Formula

(C14H21NO11)n

Molecular Weight

~1-2 MDa (high molecular weight)

Also known as: Hyaluronan, Sodium Hyaluronate, HA

What does Hyaluronic Acid do for skin?

Glycosaminoglycan that binds up to 1,000x its weight in water. High molecular weight (>1 MDa) forms a moisture-retaining film on the skin surface. Low molecular weight (<50 kDa) penetrates the epidermis and provides hydration from within. Signals through CD44 receptors to promote keratinocyte differentiation and wound healing.

Typical concentration: 0.1-2% (most formulas use 0.5-1%)

Is Hyaluronic Acid safe?

Excellent safety profile. No sensitization or irritation potential. CIR Expert Panel: safe as used in cosmetics. Naturally present in human connective tissue.

What does the research say about Hyaluronic Acid?

Regulatory Info

Status: Approved
Restrictions: Hyaluronic acid

Can I mix Hyaluronic Acid with other ingredients?

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General guidance

Hyaluronic acid works best on damp skin. Apply right after cleansing while your face is still moist for maximum hydration.

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Ceramides

HA draws water in, ceramides lock it in. Apply HA on damp skin first, then ceramide moisturizer to seal.

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Niacinamide

Excellent pair! Hyaluronic acid hydrates while niacinamide strengthens the skin barrier. Use together for plump, healthy skin.

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Retinoids

Hyaluronic acid before retinoid helps buffer irritation and keeps skin hydrated. A great way to ease into retinoids.

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Centella Asiatica (Cica)

Centella + hyaluronic acid provides deep hydration with calming benefits. Great for sensitive or irritated skin.

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Snail Mucin

Both are hydration powerhouses. Layer hyaluronic acid first (thinner), then snail mucin (thicker) for max hydration.

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Growth Factors

Hyaluronic acid on damp skin followed by growth factors ensures hydration and maximizes EGF/PDRN absorption.

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Fermented Ingredients

Fermented first essences prep the skin for better hyaluronic acid absorption. Apply fermented product first.

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Peptides

Hyaluronic acid + peptides is a hydrating anti-aging duo. Apply HA first (thinner), then peptide serum.

Read all ingredient interaction guides for layering order and science-backed advice.

All Ingredients

Frequently Asked Questions

What does Hyaluronic Acid do in skincare?+

Humectant that draws moisture into skin. Glycosaminoglycan that binds up to 1,000x its weight in water. High molecular weight (>1 MDa) forms a moisture-retaining film on the skin surface. Low molecular weight (<50 kDa) penetrates the epidermis and provides hydration from within. Signals through CD44 receptors to promote keratinocyte differentiation and wound healing.

Is Hyaluronic Acid safe for sensitive skin?+

Excellent safety profile. No sensitization or irritation potential. CIR Expert Panel: safe as used in cosmetics. Naturally present in human connective tissue.

What percentage of Hyaluronic Acid should I look for?+

Look for products with 0.1-2% (most formulas use 0.5-1%) for clinical efficacy.

Can I use Hyaluronic Acid with General guidance?+

Hyaluronic Acid can be used with General guidance. Hyaluronic acid works best on damp skin. Apply right after cleansing while your face is still moist for maximum hydration.

Can I use Hyaluronic Acid with Ceramides?+

Hyaluronic Acid can be used with Ceramides. HA draws water in, ceramides lock it in. Apply HA on damp skin first, then ceramide moisturizer to seal.

Can I use Hyaluronic Acid with Niacinamide?+

Hyaluronic Acid can be used with Niacinamide. Excellent pair! Hyaluronic acid hydrates while niacinamide strengthens the skin barrier. Use together for plump, healthy skin.

Can I use Hyaluronic Acid with Retinoids?+

Hyaluronic Acid can be used with Retinoids. Hyaluronic acid before retinoid helps buffer irritation and keeps skin hydrated. A great way to ease into retinoids.

Further Reading