Gluconolactone

A polyhydroxy acid (PHA) that acts as a gentle exfoliant and humectant. Gluconolactone, a polyhydroxy acid (PHA), gently exfoliates the skin by weakening the bonds (corneodesmosomes) between corneocytes in the stratum corneum, facilitating their shedding without causing significant irritation. It also acts as a humectant, attracting and binding water to the skin to enhance hydration. Additionally, it possesses antioxidant properties, capable of chelating metal ions and scavenging free radicals to protect against oxidative damage and support skin barrier function.

The CIR Expert Panel has deemed Gluconolactone safe for use in cosmetic formulations in concentrations up to 15% (leave-on) and 10% (rinse-off). It is generally well-tolerated, demonstrating a lower potential for irritation and sensitization compared to alpha hydroxy acids (AHAs), making it suitable for sensitive skin types.

Look for products with 2-15% (most formulas use 4-10% for gentle exfoliation and hydration; higher concentrations up to 15% are used for more pronounced effects). for clinical efficacy.

Use Gluconolactone with Retinoids carefully. While PHAs are gentler than AHAs, combining with retinoids still increases exfoliation. Monitor for irritation.

Use Gluconolactone with AHAs (Glycolic, Lactic, etc.) carefully. Using AHA and PHA together increases total exfoliation. PHAs are gentle but adding them to AHAs may be too much for sensitive skin.