Tocopheryl Acetate

토코페릴아세테이트

Goodantioxidant

A stable form of Vitamin E that acts as an antioxidant and emollient.

What is Tocopheryl Acetate?

CAS Number

52225-20-4

Formula

C31H52O3

Molecular Weight

472.7 g/mol

Also known as: DL-alpha-Tocopherol acetate, all-rac-alpha-Tocopheryl acetate, (+-)-alpha-Tocopherol acetate, WR1WPI7EW8, Alpha-tocopherol acetate, dl-

What does Tocopheryl Acetate do for skin?

Tocopheryl acetate is a pro-vitamin that penetrates the stratum corneum upon topical application and is subsequently hydrolyzed by esterases present in the skin to release free alpha-tocopherol (Vitamin E). Alpha-tocopherol then acts as a potent lipid-soluble antioxidant, scavenging reactive oxygen species (ROS) such as singlet oxygen, superoxide radicals, and hydroxyl radicals. This action protects cell membranes, lipids, and proteins from oxidative damage and lipid peroxidation, thereby mitigating premature skin aging and reducing damage induced by UV radiation.

Typical concentration: 0.05-10% (most formulas use 0.5-2% for antioxidant benefits)

Is Tocopheryl Acetate safe?

The Cosmetic Ingredient Review (CIR) Expert Panel has assessed Tocopheryl Acetate and found it safe for use in cosmetics. It is generally well-tolerated, with a low potential for irritation or sensitization, though rare cases of contact dermatitis have been reported.

What does the research say about Tocopheryl Acetate?

Regulatory Info

Status: Restricted

Can I mix Tocopheryl Acetate with other ingredients?

Info

Retinoids

Vitamin E protects retinol from oxidation and helps buffer irritation. Many retinol formulas include vitamin E for exactly this reason — a smart combination for your PM routine.

Info

Vitamin C

Vitamin C and Vitamin E are a synergistic antioxidant duo. Vitamin E stabilizes vitamin C, extending its potency and boosting UV protection together.

Read all ingredient interaction guides for layering order and science-backed advice.

All Ingredients

Frequently Asked Questions

What does Tocopheryl Acetate do in skincare?+

A stable form of Vitamin E that acts as an antioxidant and emollient. Tocopheryl acetate is a pro-vitamin that penetrates the stratum corneum upon topical application and is subsequently hydrolyzed by esterases present in the skin to release free alpha-tocopherol (Vitamin E). Alpha-tocopherol then acts as a potent lipid-soluble antioxidant, scavenging reactive oxygen species (ROS) such as singlet oxygen, superoxide radicals, and hydroxyl radicals. This action protects cell membranes, lipids, and proteins from oxidative damage and lipid peroxidation, thereby mitigating premature skin aging and reducing damage induced by UV radiation.

Is Tocopheryl Acetate safe for sensitive skin?+

The Cosmetic Ingredient Review (CIR) Expert Panel has assessed Tocopheryl Acetate and found it safe for use in cosmetics. It is generally well-tolerated, with a low potential for irritation or sensitization, though rare cases of contact dermatitis have been reported.

What percentage of Tocopheryl Acetate should I look for?+

Look for products with 0.05-10% (most formulas use 0.5-2% for antioxidant benefits) for clinical efficacy.

Can I use Tocopheryl Acetate with Retinoids?+

Tocopheryl Acetate can be used with Retinoids. Vitamin E protects retinol from oxidation and helps buffer irritation. Many retinol formulas include vitamin E for exactly this reason — a smart combination for your PM routine.

Can I use Tocopheryl Acetate with Vitamin C?+

Tocopheryl Acetate can be used with Vitamin C. Vitamin C and Vitamin E are a synergistic antioxidant duo. Vitamin E stabilizes vitamin C, extending its potency and boosting UV protection together.

Further Reading