Alpha Arbutin

Goodactive

Skin brightener that inhibits melanin production to reduce hyperpigmentation.

What is Alpha Arbutin?

CAS Number

84380-01-8

Formula

C12H16O7

Molecular Weight

272.25 g/mol

Also known as: 4-Hydroxyphenyl alpha-D-glucopyranoside, Alpha-Arbutin

What does Alpha Arbutin do for skin?

Glycosylated hydroquinone derivative that inhibits tyrosinase without the cytotoxicity of free hydroquinone. The alpha-glucoside bond provides 10x stronger tyrosinase inhibition than beta-arbutin. Reduces melanin synthesis by competing with L-DOPA at the tyrosinase active site. Does not release free hydroquinone under normal physiological conditions.

Typical concentration: 0.5-2% (most effective at 1-2%)

Is Alpha Arbutin safe?

Good safety profile. Non-cytotoxic unlike hydroquinone. CIR Expert Panel: safe up to 2% in leave-on products. No photosensitivity concerns.

What does the research say about Alpha Arbutin?

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Frequently Asked Questions

What does Alpha Arbutin do in skincare?+

Skin brightener that inhibits melanin production to reduce hyperpigmentation. Glycosylated hydroquinone derivative that inhibits tyrosinase without the cytotoxicity of free hydroquinone. The alpha-glucoside bond provides 10x stronger tyrosinase inhibition than beta-arbutin. Reduces melanin synthesis by competing with L-DOPA at the tyrosinase active site. Does not release free hydroquinone under normal physiological conditions.

Is Alpha Arbutin safe for sensitive skin?+

Good safety profile. Non-cytotoxic unlike hydroquinone. CIR Expert Panel: safe up to 2% in leave-on products. No photosensitivity concerns.

What percentage of Alpha Arbutin should I look for?+

Look for products with 0.5-2% (most effective at 1-2%) for clinical efficacy.

Further Reading

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