Xylitol
A sugar alcohol that acts as a humectant, drawing moisture to the skin, and can also have antimicrobial properties.
What is Xylitol?
CAS Number
488-81-3
Formula
C5H12O5
Molecular Weight
152.15 g/mol
Also known as: (2S,4R)-pentane-1,2,3,4,5-pentol, RefChem:934805, GlyTouCan:G06874YZ, G06874YZ, xylitol
What does Xylitol do for skin?
Xylitol, a sugar alcohol, acts as a humectant by attracting and binding water molecules from the environment and deeper epidermal layers, thereby increasing skin hydration and reducing transepidermal water loss. It also supports skin barrier function by promoting the synthesis of ceramides and enhancing the expression of aquaglyceroporin 3 (AQP3) in keratinocytes, facilitating water and glycerol transport crucial for maintaining skin moisture and integrity.
Typical concentration: 1-10% (most formulas use 2-5%)
Is Xylitol safe?
The Cosmetic Ingredient Review (CIR) Expert Panel assessed Xylitol and found it safe as a cosmetic ingredient in current practices of use and concentration. It is generally well-tolerated and considered non-irritating and non-sensitizing for topical application.
What does the research say about Xylitol?
The humectant effect of xylitol and its promotion of the biosynthesis of epidermal ceramides
Hatanaka K, Yamato T, Sano M, Oizumi H. J Cosmet Sci. 2011 Sep-Oct;62(5):455-64.
Xylitol Enhances Expression of Aquaporin 3 and Increases Skin Hydration in Vitro and in Vivo
Hatanaka K, Miyahara K, Konno K, Suzuki M. J Invest Dermatol. 2014 Jun;134(6):1718-20.
Evaluation of the moisturizing effect of a topical formulation containing xylitol on facial skin
de Almeida IF, de Sousa VM, Lopes D, da Conceição N, de Sousa CA. Int J Cosmet Sci. 2020 Aug;42(4):353-359.