Squalene

Goodemollient

A lipid naturally found in skin that helps to moisturize and protect.

What is Squalene?

CAS Number

111-02-4

Formula

C30H50

Molecular Weight

410.7 g/mol

Also known as: squalene, Spinacene, trans-Squalene, All-trans-Squalene, Spinacen

What does Squalene do for skin?

Squalene, a natural component of human sebum and the skin's lipid barrier, functions as an excellent emollient and skin conditioning agent by forming a protective film on the skin surface. This film helps to reduce transepidermal water loss (TEWL), thereby improving skin hydration and maintaining barrier integrity. Additionally, squalene possesses antioxidant properties, protecting skin lipids from oxidative damage caused by free radicals, particularly those generated by UV exposure.

Typical concentration: 0.1-5% (due to its susceptibility to oxidation, higher concentrations are rarely used; its hydrogenated form, squalane, is used at much higher concentrations up to 100%)

Is Squalene safe?

Squalene is generally considered safe for topical cosmetic use and is a natural component of human sebum. While the CIR Expert Panel assessed the related ingredient Squalane as safe, squalene itself is prone to oxidation; however, the pure form is not associated with irritation or sensitization.

What does the research say about Squalene?

Regulatory Info

Status: Approved
Restrictions: 2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene

Can I mix Squalene with other ingredients?

Info

General guidance

Squalane and face oils should be your last step (before SPF in AM). They create an occlusive layer that seals everything in.

Info

Retinoids

Squalane after retinoid helps lock in moisture and reduce dryness. It's non-comedogenic so it won't clog pores.

Read all ingredient interaction guides for layering order and science-backed advice.

All Ingredients

Frequently Asked Questions

What does Squalene do in skincare?+

A lipid naturally found in skin that helps to moisturize and protect. Squalene, a natural component of human sebum and the skin's lipid barrier, functions as an excellent emollient and skin conditioning agent by forming a protective film on the skin surface. This film helps to reduce transepidermal water loss (TEWL), thereby improving skin hydration and maintaining barrier integrity. Additionally, squalene possesses antioxidant properties, protecting skin lipids from oxidative damage caused by free radicals, particularly those generated by UV exposure.

Is Squalene safe for sensitive skin?+

Squalene is generally considered safe for topical cosmetic use and is a natural component of human sebum. While the CIR Expert Panel assessed the related ingredient Squalane as safe, squalene itself is prone to oxidation; however, the pure form is not associated with irritation or sensitization.

What percentage of Squalene should I look for?+

Look for products with 0.1-5% (due to its susceptibility to oxidation, higher concentrations are rarely used; its hydrogenated form, squalane, is used at much higher concentrations up to 100%) for clinical efficacy.

Can I use Squalene with General guidance?+

Squalene can be used with General guidance. Squalane and face oils should be your last step (before SPF in AM). They create an occlusive layer that seals everything in.

Can I use Squalene with Retinoids?+

Squalene can be used with Retinoids. Squalane after retinoid helps lock in moisture and reduce dryness. It's non-comedogenic so it won't clog pores.