Propylparaben
프로필파라벤
Preservative that prevents microbial growth.
What is Propylparaben?
CAS Number
94-13-3
Formula
C10H12O3
Molecular Weight
180.20 g/mol
Also known as: PROPYLPARABEN, Propyl paraben, Nipasol, Propyl p-hydroxybenzoate, Nipazol
What does Propylparaben do for skin?
Propylparaben functions as a broad-spectrum antimicrobial preservative within cosmetic formulations. It exerts its action by disrupting the cell membranes of bacteria, yeasts, and molds, leading to the leakage of intracellular components, inhibition of enzyme systems, and denaturation of proteins in microorganisms. This activity effectively prevents microbial growth and spoilage of the cosmetic product, thereby maintaining its integrity, efficacy, and safety for application on the skin.
Typical concentration: 0.01-0.19% (when used as a single paraben; the total concentration of parabens in a blend should not exceed 0.8% in regulated regions like the EU). Most formulations utilize concentrations towards the lower end of this range, often in combination with other preservatives for synergistic effect.
Is Propylparaben safe?
The CIR Expert Panel has reaffirmed Propylparaben as safe for use in cosmetics at current concentrations. It is generally recognized as safe by the FDA. While it has a low potential for sensitization or irritation, rare cases of allergic contact dermatitis have been reported, and concerns regarding potential endocrine disruption are under ongoing scientific review, though regulatory bodies consider current use levels safe.
What does the research say about Propylparaben?
Fiume MZ, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA. International Journal of Toxicology, 2019 Nov/Dec
Mechanism of antimicrobial action of parabens, phenol and sodium benzoate.
Anagnostopoulos E, Kazanis M, Psarrou E, Karageorgiou T, Demetriou A, Mavreas T. Microbios, 1978
Contact allergy to parabens: a re-evaluation.
Lundov MD, Avenel-Audran M. Contact Dermatitis, 2017 Aug