Homosalate
호모살레이트
A chemical sunscreen filter that absorbs UVB radiation.
What is Homosalate?
CAS Number
118-56-9
Formula
C16H22O3
Molecular Weight
262.34 g/mol
Also known as: Homosalate, Homomenthyl salicylate, Heliophan, Homosalato, Homosalatum
What does Homosalate do for skin?
Homosalate is an organic ultraviolet (UV) filter that works by absorbing UVB radiation, primarily in the range of 290-320 nm. Upon absorption of UV photons, the molecule undergoes an excitation to a higher energy state. This absorbed energy is then safely dissipated as heat through a photostable process, typically involving internal conversion, preventing the harmful UV radiation from penetrating and damaging skin cells. This action effectively protects the skin from UVB-induced erythema and sunburn.
Typical concentration: Homosalate is typically used in cosmetic formulations as an active sunscreen ingredient at concentrations ranging from 1-15%. The U.S. FDA Monograph for sunscreen active ingredients permits its use up to 15%.
Is Homosalate safe?
The Cosmetic Ingredient Review (CIR) Expert Panel has assessed Homosalate and reaffirmed its safety for use in cosmetics in current practices and concentrations. The U.S. FDA has approved Homosalate as an over-the-counter (OTC) sunscreen active ingredient. It is generally well-tolerated with a low potential for irritation or sensitization, though some studies have raised questions regarding potential systemic absorption and endocrine activity, warranting further research.
What does the research say about Homosalate?
Systemic absorption of sunscreen ingredients: a review
Matta MK, et al. Br J Dermatol. 2019 Dec 22.
Sambandan DR, Ratner D. J Am Acad Dermatol. 2011 May;64(5):1017-28.
Photostability of organic and inorganic UV filters: a systematic review
Saraceni F, et al. Int J Cosmet Sci. 2019 Aug;41(4):313-322.