Ergothioneine

Goodantioxidant

A potent antioxidant that helps protect skin from oxidative stress and environmental damage.

What is Ergothioneine?

CAS Number

497-30-3

Formula

C9H15N3O2S

Molecular Weight

229.30 g/mol

Also known as: ERGOTHIONEINE, L-Ergothioneine, Sympectothion, Ergothionine, Thioneine

What does Ergothioneine do for skin?

Ergothioneine is a potent, naturally occurring antioxidant amino acid that protects skin cells from oxidative damage induced by environmental stressors like UV radiation and pollution. It functions as a reactive oxygen species (ROS) scavenger, neutralizes free radicals, and safeguards cellular components, including DNA, proteins, and lipids. Its unique uptake via the organic cation transporter OCTN1 (SLC22A4) allows for efficient accumulation within cells, particularly in mitochondria, to protect against oxidative stress and support cellular energy metabolism, thereby contributing to anti-aging and photoprotective effects.

Typical concentration: 0.01-0.5% (most formulas use 0.05-0.2%)

Is Ergothioneine safe?

Ergothioneine is generally considered safe and well-tolerated for topical cosmetic use, with no significant irritation or sensitization potential reported. It is a naturally occurring compound and widely used in cosmetic formulations.

What does the research say about Ergothioneine?

Regulatory Info

Status: Approved
Restrictions: Ammonium, [1-carboxy-2-(2-mercaptoimidazol-4-yl)ethyl]trimethyl-, hydroxide, inner salt, L-(+)-
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Frequently Asked Questions

What does Ergothioneine do in skincare?+

A potent antioxidant that helps protect skin from oxidative stress and environmental damage. Ergothioneine is a potent, naturally occurring antioxidant amino acid that protects skin cells from oxidative damage induced by environmental stressors like UV radiation and pollution. It functions as a reactive oxygen species (ROS) scavenger, neutralizes free radicals, and safeguards cellular components, including DNA, proteins, and lipids. Its unique uptake via the organic cation transporter OCTN1 (SLC22A4) allows for efficient accumulation within cells, particularly in mitochondria, to protect against oxidative stress and support cellular energy metabolism, thereby contributing to anti-aging and photoprotective effects.

Is Ergothioneine safe for sensitive skin?+

Ergothioneine is generally considered safe and well-tolerated for topical cosmetic use, with no significant irritation or sensitization potential reported. It is a naturally occurring compound and widely used in cosmetic formulations.

What percentage of Ergothioneine should I look for?+

Look for products with 0.01-0.5% (most formulas use 0.05-0.2%) for clinical efficacy.