Coumarin
쿠마린
Fragrance ingredient, can be a potential allergen for some individuals.
What is Coumarin?
CAS Number
91-64-5
Formula
C9H6O2
Molecular Weight
146.14 g/mol
Also known as: coumarin, cumarin, chromen-2-one, Tonka bean camphor, Rattex
What does Coumarin do for skin?
Coumarin primarily functions as a fragrance ingredient by volatilizing from the skin surface to stimulate olfactory receptors, imparting a sweet, vanilla-like aroma. While it does not exert direct therapeutic actions on skin physiology, it can interact with epidermal cells upon absorption, which is relevant to its potential to induce sensitization.
Typical concentration: Typically used at very low concentrations, generally below 0.1%, with specific maximum limits (ranging from 0.002% to 0.06%) depending on the product category and regulatory standards (e.g., IFRA, EU Cosmetics Regulation) due to its sensitizing potential. EU regulations require labeling if concentrations exceed 0.001% in leave-on products or 0.01% in rinse-off products.
Is Coumarin safe?
Coumarin is a well-known fragrance allergen and is listed among the 26 substances requiring declaration in the EU. It has the potential to induce skin sensitization and allergic contact dermatitis in susceptible individuals. The CIR Expert Panel has not specifically reviewed coumarin, but its safety as a fragrance has been extensively assessed by the SCCS in the EU and IFRA.
What does the research say about Coumarin?
Coumarin--an allergen of fragrances: results of the IVDK patch test study in 2011
Johansen JD, Frosch PJ, Lepoittevin JP, Elsner P, Maibach H, Rastogi S, SCCS. Contact Dermatitis. 2013 Jul;69(1):15-22.
Uter W, Johansen JD, Aberer W, Bergman E, Bircher AJ, Bruynzeel DP, Cooper SM, J. Contact Dermatitis. 2016 Aug;75(2):98-106.
The 26 fragrance allergens and their prevalence in products and in patch test results
Scheman A, Atwater A, Bhate C, Burrall B, Chow L, Cohen D, Davis MDP, Deleo VA, Fransway AF, Fowler JF Jr, Gaspari AA, Hamann C, Hsu JW, Maibach HI, Marks JG Jr, Mathias CGT, Pratt MD, Robinson M, Sasseville D, Schalock PC, Schwarzenberger K, Silverberg NB, Silverberg JI, Taylor JS, Warshaw EM. Dermatitis. 2014 Mar-Apr;25(2):50-7.