Cholesterol

Skin-conditioning agent and emollient that helps maintain the skin barrier. Cholesterol is a vital lipid component of the stratum corneum, working synergistically with ceramides and free fatty acids to form the highly organized lamellar structures of the skin barrier. It contributes to the optimal fluidity and organization of the intercellular lipid matrix, which is essential for maintaining barrier integrity and reducing transepidermal water loss (TEWL). Topically, it helps to reinforce and repair compromised skin barriers, enhancing skin hydration, smoothness, and protection against external stressors and irritants.

Cholesterol is a naturally occurring component of the skin and is considered safe for cosmetic use. The Cosmetic Ingredient Review (CIR) Expert Panel concluded that cholesterol is safe as a cosmetic ingredient. It generally exhibits a very low potential for irritation or sensitization.

Look for products with 0.05-1.0% (commonly used in combination with ceramides and fatty acids, often in specific physiological ratios like 3:1:1, to support barrier function). for clinical efficacy.