Arginine

Goodother

An amino acid that helps maintain skin hydration and supports skin barrier function.

What is Arginine?

CAS Number

74-79-3

Formula

C6H14N4O2

Molecular Weight

174.20 g/mol

Also known as: L-arginine, arginine, L-(+)-Arginine, (S)-2-Amino-5-guanidinopentanoic acid, L-Arg

What does Arginine do for skin?

Arginine, an alpha-amino acid, acts as a humectant by attracting and binding water molecules, thereby improving stratum corneum hydration and skin barrier function. It also serves as a precursor for nitric oxide (NO) via nitric oxide synthase (NOS) activity, contributing to vasodilation, wound healing, and antioxidant defense in the skin. Furthermore, Arginine contributes to the skin's Natural Moisturizing Factor (NMF) and helps buffer the skin's pH, supporting optimal enzyme activity and barrier integrity.

Typical concentration: Typical concentrations range from 0.1-10% in leave-on products and up to 13.2% in rinse-off products. Many formulations utilize 0.5-5% for skin conditioning, hair conditioning, and pH adjustment.

Is Arginine safe?

The Cosmetic Ingredient Review (CIR) Expert Panel has assessed Arginine and concluded it is safe for use in cosmetics. It is naturally occurring in the skin and generally recognized as having low irritation and sensitization potential.

What does the research say about Arginine?

Regulatory Info

Status: Approved
Restrictions: L-Arginine
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Frequently Asked Questions

What does Arginine do in skincare?+

An amino acid that helps maintain skin hydration and supports skin barrier function. Arginine, an alpha-amino acid, acts as a humectant by attracting and binding water molecules, thereby improving stratum corneum hydration and skin barrier function. It also serves as a precursor for nitric oxide (NO) via nitric oxide synthase (NOS) activity, contributing to vasodilation, wound healing, and antioxidant defense in the skin. Furthermore, Arginine contributes to the skin's Natural Moisturizing Factor (NMF) and helps buffer the skin's pH, supporting optimal enzyme activity and barrier integrity.

Is Arginine safe for sensitive skin?+

The Cosmetic Ingredient Review (CIR) Expert Panel has assessed Arginine and concluded it is safe for use in cosmetics. It is naturally occurring in the skin and generally recognized as having low irritation and sensitization potential.

What percentage of Arginine should I look for?+

Look for products with Typical concentrations range from 0.1-10% in leave-on products and up to 13.2% in rinse-off products. Many formulations utilize 0.5-5% for skin conditioning, hair conditioning, and pH adjustment. for clinical efficacy.